Genetic moderation on the relationship between brain white matter hyperintensities and amyloid‐beta
Genomic variants moderated the relationship between WMH and amyloid biomarkers, suggesting a novel regulatory role for snRNA. This genome-wide interaction study highlights the potential contributions of snRNA and related pathways to the relationship between vascular disease and amyloid biomarkers in AD.
Authors
- Lisa Xiong
- Aparna Bhan
- Arun Seth (ORCID: https://orcid.org/0000-0002-5715-8736)
- Meghan J. Chenoweth (ORCID: https://orcid.org/0000-0002-8218-8240)
- Katherine Zukotynski (ORCID: https://orcid.org/0000-0003-0584-4387)
- Shiropa Noor
- Yutaka Amemiya (ORCID: https://orcid.org/0000-0002-8057-6709)
- Maged Goubran (ORCID: https://orcid.org/0000-0001-5880-0818)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Julia Keith (ORCID: https://orcid.org/0000-0003-1519-6731)
- Che‐Yuan Wu (ORCID: https://orcid.org/0000-0001-8548-1824)
- C. Heyn
- Joel Ramirez (ORCID: https://orcid.org/0000-0002-5582-1776)
- Demetrios J. Sahlas (ORCID: https://orcid.org/0000-0002-7986-3305)
- Daniel K Mori‐Fegan (ORCID: https://orcid.org/0000-0003-1290-7710)
- Christopher J.M. Scott (ORCID: https://orcid.org/0000-0002-3236-7523)
- Yong‐Chuan Wong
- Ekaterina Rogaeva
- Mario Masellis
- Si Won Ryoo
- Myuri Ruthirakuhan
- Benjamin Lam
- Sandra E. Black
- Saira S. Mirza
- Richard H. Swartz
- Walter Swardfager
- David A. A. Bennett
- Fuqiang Gao
Institutions
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of Toronto (CA)
- Heart and Stroke Foundation (CA)
- Toronto Rehabilitation Institute (CA)
- Health Sciences Centre (CA)
- Toronto Dementia Research Alliance (CA)
- Occupational Cancer Research Centre (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- Rush University (US)
- McMaster University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103613
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00