Single‐nucleus transcriptomics and deep learning uncover alternative polyadenylation dysregulation in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

This study provides a comprehensive single-nucleus transcriptomic atlas of the frontal cortex in ALS with and without FTLD, uncovering cell type-specific dysregulation of APA and RBP interactions. Our findings offer new insights into the molecular mechanisms driving FTLD and provide a resource for future therapeutic development.