Single‐nucleus transcriptomic and chromatin accessibility analysis of rat hippocampal cells following amyloid‐beta oligomers injections
This study will allow us to determine the gene expression and epigenetic changes induced specifically by Aß oligomers in each hippocampal cell type during the progression of Aß pathology. This could pave the way to find new therapeutic targets efficiently in the early stages of AD.
Authors
- Jonathan Brouillette (ORCID: https://orcid.org/0000-0003-1058-1892)
- Klarissa Leduc
- Tra‐My Vu
- Martin Newton
Institutions
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103834
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00