Glymphatic perivascular clearance and extracellular vesicles: neuroimaging & blood‐based biomarkers in mild cognitive impairment
These preliminary results suggest that glymphatic dysfunction estimated by the DTI-ALPS index is associated with brain atrophy, where the left hemisphere DTI-ALPS is associated with executive dysfunction in both CN and MCI. Additionally, GFAP/GAL3 may be a potential useful astrocytic EV biomarker to indicate dysfunction of perivascular space clearance. Future work will examine mediation models with these imaging and EV biomarkers in neurodegenerative clinical populations.
Authors
- Shawn N. Whitehead (ORCID: https://orcid.org/0000-0003-4728-8067)
- Daniela Andriuta (ORCID: https://orcid.org/0000-0002-1191-7178)
- Austyn D. Roseborough (ORCID: https://orcid.org/0000-0001-7823-8199)
- Stephanie Berberian
- Lauren Abby Woods
- Sandra E. Black
- Jeng‐liang Wu
- Ramirez Joel
- Min Su Kang
- Manuel Montero‐Odasso
- Erin Gibson
Institutions
- Western University (CA)
- Sunnybrook Health Science Centre (CA)
- Health Sciences Centre (CA)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Ontario Brain Institute (CA)
- Université de Picardie Jules Verne (FR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100920
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00