The Association of UCHL5 Levels with AT(N) Biomarkers
These findings reveal intriguing correlations between AT(N) biomarkers and CSF UCHL5 levels, suggesting a potential role for this protein across different stages of Alzheimer's disease. However, further analyses are needed to clarify UCHL5's involvement in early tau accumulation, clinical conversion, and the degradation of misfolded proteins associated with AD proteinopathies, as well as its impact on neurodegeneration.
Authors
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Gabriela Mantovani Baldasso
- Sofia Gallo Salvadori
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105205
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81