Normal pressure hydrocephalus – potentially treatable dementia and window for living human brain

Amyloid plaques even in tiny frontal (or parietal) brain biopsy taken during shunt surgery can indicate high risk of comorbid clinical AD and together with tau, neuropathologically verified biological AD or rarely seen tau pathology alone, a primary tauopathy like frontotemporal dementia (FTD). Furthermore, obtainment of living human brain samples, are valuable for omics techniques and imaging at single cell level to uncover individual cell level disease mechanisms related with NPH and AD as well as other neurodegenerative diseases seen in NPH patients and hampering their prognosis.