VPS25 alleviates depression-like behavior in rats by inhibiting apoptosis in the hippocampus

These results indicate that silencing VPS25 alleviates depression symptoms by promoting autophagy and inhibiting neuronal apoptosis, partly through the JAK/STAT signaling pathway.

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Publication Details

Journal
Brain Research Bulletin
Published
2025-12-24
DOI
https://doi.org/10.1016/j.brainresbull.2025.111705
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

VPS25 alleviates depression-like behavior in rats by inhibiting apoptosis in the hippocampus

Bing Hou, Yigao Wu, Sifan Xu, Xiaofang Huang et al.
Brain Research Bulletin
Tryptophan and brain disorders
article

VPS25 alleviates depression-like behavior in rats by inhibiting apoptosis in the hippocampus

Bing Hou, Yigao Wu, Sifan Xu, Xiaofang Huang, Qi Wang, Jiucui Tong, Zhiming Zhou, Lili Yuan
article en

Abstract

These results indicate that silencing VPS25 alleviates depression symptoms by promoting autophagy and inhibiting neuronal apoptosis, partly through the JAK/STAT signaling pathway.

Brain Research BulletinVol. 234
Wannan Medical College (CN), First Affiliated Hospital of Wannan Medical College (CN)
Good health and well-being
Openalex Percentile: Top 47%
Tryptophan and brain disorders
DOIOpen Access PDFOpenAlex
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