In-situ dual-lighting system for HER2 nucleic acid and protein co-localization through simultaneous visual signal amplification in single pathological sections
ISDLS enables the spatial in-situ distribution of amplified nucleic acid and protein signals in one section, providing a basis for multidimensional analysis of diseases. ISDLS is also expected to improve the speed, sensitivity, and accuracy of detection compared to other methods.
Authors
- Ang Yu Liu
- T. J. Wang
- Bei Hu
- Liang Zhang (ORCID: https://orcid.org/0000-0002-2694-1779)
- Lin Chen (ORCID: https://orcid.org/0000-0002-1587-7564)
- Qinglin Zhang (ORCID: https://orcid.org/0000-0002-3640-2883)
- Qunyue Wu
- Weiyang Liang
- Shan Li
- Yao Huang
- Xuan Fu
- Zhiqing Chen
- Xin Li
Institutions
- Guangdong Institute for Drug Control (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1038/s43856-025-01327-2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial People's Hospital