Aβ <sub>42</sub> regulates ER cholesterol turnover to modulate ER‐microtubule contact tethering and alter Tau dynamics in Alzheimer's disease
Our work provides evidence for a unifying mechanism linking Aβ function with tau dynamics through cholesterol-mediated ER dynamics, and identifies a novel cellular pathway underlying AD pathogenesis.
Authors
- Tayler B. Belton
- George C. Shum (ORCID: https://orcid.org/0000-0001-5464-0570)
- Eric D. Leisten (ORCID: https://orcid.org/0009-0005-7469-6009)
- Yvette C. Wong (ORCID: https://orcid.org/0000-0002-3188-4342)
- A Woods (ORCID: https://orcid.org/0009-0009-3538-0393)
- Kevin R Shen
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101226
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00