IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccine
Controlled human malaria infections after immunization via mosquito bites with radiation attenuated Plasmodium falciparum sporozoites are necessary tools to decipher immune signatures of malaria protection. The phenotype of circulating mononuclear innate cells and the PBMC response to in vitro stimulation unraveled correlates of protection from baseline immune response to sporozoite stimulation (IFN-ƴ secretion and HLA-DR<sup>high</sup> expression) to vaccine-induced immune factors (IL-4 secretion and CD57<sup>-</sup> γδ T cell frequency).
Authors
- Tanisha M. Robinson
- Jessica S. Bolton
- Elke Bergmann-Leitner
- Marie Mura (ORCID: https://orcid.org/0000-0003-0051-3773)
- Elisabeth H. Duncan
Institutions
- HIA du Val-de-Grâce à Paris (FR)
- Biologie et Génétique des Interactions Plante-Parasite (FR)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- npj Vaccines
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1038/s41541-025-01308-5
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Medical Research Council
- Naval Medical Research Center