Relationship between Polygenetic Risk Score of BrainAge and plasma biomarkers in the A4/LEARN studies
Genetic factors associated with increased propensity for accelerated brain aging in the grey matter is associated with p-tau<sub>217</sub>, an early and sensitive marker of AD. These genetic predispositions were more pronounced in older age, highlighting the importance of age as a critical factor that may interact with genetic susceptibility to brain aging, potentially through cumulative lifetime exposures, increasing vascular burden, or age-related declines in cellular repair mechanisms. Associations solely with BrainAge GM PRS implies the specificity of accelerated brain aging in grey matter as a potential early marker of AD risk.
Authors
- Aaron P. Schultz (ORCID: https://orcid.org/0000-0002-0418-0999)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Jorge García Condado (ORCID: https://orcid.org/0000-0002-9463-1924)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Asier Erramuzpe (ORCID: https://orcid.org/0000-0002-9402-2184)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hannah M Klinger
- Cortes Jesús
- K. A. Johnson
- R. Sperling
- Hyun‐Sik Yang
- Michael J. Properzi
- Dorene M. Rentz
- Mabel Seto
Institutions
- Ikerbasque (ES)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- The University of Melbourne (AU)
- University of the Basque Country (ES)
- Massachusetts General Hospital (US)
- BioCruces Health research Institute (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106684
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00