The role of lysosomal depalmitoylation in Alzheimer's Disease in vitro and in vivo models
PPT1 delays AD pathology and induces differential changes in gene and protein levels that affect amyloidogenic pathways activating autophagy/lysosomal processes.
Authors
- Christina Muratore
- James G. Patton (ORCID: https://orcid.org/0000-0001-5749-0870)
- Matthew J Rosene (ORCID: https://orcid.org/0000-0002-4243-3678)
- Bruno A. Benítez (ORCID: https://orcid.org/0000-0002-2699-3878)
- Adeeb Uddin Ahmad
- Skarleth Cardenas Romero
- Mei‐Yu Lai
- Abraham Lopez
- Natalia López Herrera
- Gabriel Pagan Gonzalez
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Beth Israel Deaconess Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105339
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00