A single‐cell atlas of cerebrospinal fluid in Alzheimer's disease

We revealed differences in the transcriptional signatures of immune cells in the CSF of sLOAD and sEOAD. In further studies, we plan to collect the publicly available scRNA-seq of brain from AD patients with age of disease onset information and combine these with our scRNA-seq data of CSF for integrated analysis to reveal the potential interactions between immune cells in CSF and brain parenchyma.