Cognitively resilient individuals show enrichment for <i>MS4A</i> gene SNPs and postmortem amyloid‐responsive microglia

Microglial specific MS4A6A SNP, which modulates microglial activation, was seen in a third of CR individuals. Postmortem analyses in CR individuals revealed increased ARM:amyloid, which was also associated with higher antemortem cognitive performance. These findings underscore the role of microglial activation in cognitive resilience. Future work is needed to investigate microglial protective mechanisms and links between vascular disease and microglial activation.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_106867
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Cognitively resilient individuals show enrichment for MS4A gene SNPs and postmortem amyloid‐responsive microglia

Ekaterina I. Hofrenning, Jonathan Graff‐Radford, Scott A. Przybelski, Aivi T. Nguyen et al.
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
article

Cognitively resilient individuals show enrichment for MS4A gene SNPs and postmortem amyloid‐responsive microglia

Ekaterina I. Hofrenning, Jonathan Graff‐Radford, Scott A. Przybelski, Aivi T. Nguyen, R. C. Petersen, David S. Knopman, Vijay K. Ramanan, R. Ross Reichard, Clifford R. Jack, Prashanthi Vemuri
article en

Abstract

Microglial specific MS4A6A SNP, which modulates microglial activation, was seen in a third of CR individuals. Postmortem analyses in CR individuals revealed increased ARM:amyloid, which was also associated with higher antemortem cognitive performance. These findings underscore the role of microglial activation in cognitive resilience. Future work is needed to investigate microglial protective mechanisms and links between vascular disease and microglial activation.

Alzheimer s & DementiaVol. 21(S1)
Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Openalex Percentile: Top 39%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
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Cognitively resilient individuals show enrichment for <i>MS4A</i> gene SNPs and postmortem amyloid‐responsive microglia — Ekaterina I. Hofrenning, Jonathan Graff‐Radford, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS