Memory performance in the preclinical stage of ADAD: The influence of APOE ε4 on <i> PSEN1 <sub>A431E</sub> </i> and <i> APP <sub>V717I</sub> </i> Carriers
Our findings indicate early visual memory impairment preceding the ADAD clinical stage in this carrier population. However, no evidence was found to indicate a negative impact of APOE ε4 on memory performance. Future efforts to expand the sample size will be essential to confirm whether the observed pattern persists and to uncover potential effects on other cognitive domains. Additionally, factors such as proximity to symptom onset and APOE ancestry may also influence cognitive performance. This study contributes to understanding early cognitive changes in ADAD and suggests that factors modifying the clinical phenotype may also play a role in shaping preclinical cognitive variations.
Authors
- Esmeralda Matute (ORCID: https://orcid.org/0000-0003-0118-9960)
- Angélica Zuno‐Reyes
- John M. Ringman (ORCID: https://orcid.org/0000-0001-5429-0777)
- Sofía Dumois‐Petersen (ORCID: https://orcid.org/0009-0003-5858-8978)
- Isaac Enrique Berumen‐Ocegueda
- Ana Karen Preciado‐Baron
- Ricardo Jauregui Torres
- Figuera Luis E.
- César A Valdez‐Gaxiola
- Frida Rosales‐Leycegui
- Karina Pérez‐Rubio
Institutions
- University of Southern California (US)
- Mexican Social Security Institute (MX)
- Universidad de Guadalajara (MX)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102487
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00