Genome‐wide interaction and stratified study reveals <i>CR1</i> ‐Alzheimer's disease association is moderated by education level
In educational attainment-stratified GWAS of AD, we identified stronger association of known AD-related gene CR1, among those with lower educational attainment. The finding implicating CR1, a complement pathway gene, suggests that the risk education confers on AD may be moderated by immune-related mechanisms.
Authors
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Lindsay A. Farrer (ORCID: https://orcid.org/0000-0001-5533-4225)
- Bobak Abdolmohammadi
- Max Rosenthaler (ORCID: https://orcid.org/0000-0002-4302-1691)
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Shruti Durape
- Kathryn L. Lunetta (ORCID: https://orcid.org/0000-0002-9268-810X)
- Andrew Joel Saykin
- R Mayeux
- Gerald D. Schellenberg
- Jaeyoon Chung
- Walter W. Kukull
- Adam Brickman
- Jesse Mez
- Jonathan L Haines
- Ryan Dacey
- M. Ilyas Kamboh
- Paul K Crane
- Shubhabrata Mukherjee
- David A. A. Bennett
- Margaret Pericak‐Vance
- Xudong Han
Institutions
- Boston University (US)
- Rush University Medical Center (US)
- University of Miami (US)
- University of Puget Sound (US)
- University of Pittsburgh (US)
- Vanderbilt University (US)
- University of Washington (US)
- Geriatric Research Education and Clinical Center (US)
- Framingham Heart Study (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105938
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00