Chronic ghrelin administration suppresses IKK/NF‐κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ‐diabetic rats
Ghrelin binds to its receptor GHSR-1a and inhibits the activation of NF-κB, thereby inhibiting the expression of BACE1, reducing Aβ deposition, attenuating oxidative stress, and improving the learning and memory ability of diabetic rats.
Authors
- Qiumin Qu
- louyan Ma
Institutions
- Wuhan No.1 Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Hospital of Xi'an (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101492
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00