Artemisinin‐Based Combination Therapies in East Africa: A Systematic Review of Quality, Clinical Efficacy, and Regulatory Progress Towards Sustainable Malaria Control

The findings of this study revealed that 11.2% of ACTs samples were found to be poor quality. The clinical data reflects that in East Africa, ACTs remain effective despite the prevalence of substandard and falsified ACTs and emerging resistance threatening long-term gains. Thus, strengthening regional regulatory harmonization, pharmacovigilance, molecular surveillance, and local manufacturing capacity is essential to combat resistance of ACT and ensure equitable access to quality-assured therapies.