Low dose ketamine induces unique molecular and cellular responses in the brains of Alzheimer's disease mouse models
Our data show that chronic low dose ketamine induces a unique transcriptional and cellular response in the context of AD. Moreover, ketamine induces AD-like transcriptional signature in WT mice. These results indicate that ketamine may modulate AD risk and underscore the need for caution when considering low-dose ketamine in patients at risk for or diagnosed with AD.
Authors
- Mychael V. Lourenco (ORCID: https://orcid.org/0000-0002-1078-0296)
- M Boroni
- Ícaro Raony
- Cristóvão Antunes de Lanna (ORCID: https://orcid.org/0000-0002-5946-4358)
- Sérgio T. Ferreira (ORCID: https://orcid.org/0000-0001-7160-9866)
- Alinny Rosendo Isaac (ORCID: https://orcid.org/0000-0003-3162-8258)
- Fernanda Guarino De Felice
- Danielle Cozachenco
- Ricardo A S Lima‐Filho
- Ana Carolina Metello
- Gina C Couto
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Queen's University (CA)
- D’Or Institute for Research and Education (BR)
- Instituto Nacional de Câncer - INCA (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100276
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00