The Influence of Variation in Hexanucleotide Repeat Number in the 5’ Untranslated Region of Cytochrome C Oxidase Subunit 7A1 on the Development of Cognitive Impairment
In a small cross-sectional cohort (N = 296) aged 65-85 increased hexanucleotide repeat number in the 5' UTR of COX7A1 appears to negatively impact global cognition (MoCA z-score). Larger, prospective follow-up studies paired with neurodegenerative biomarkers will need to be performed to assess if this association is secondary to aging, AD neuropathological change, or other associated pathology.
Authors
- Joseph Pleen (ORCID: https://orcid.org/0000-0002-8584-1858)
- Russell Howard Swerdlow (ORCID: https://orcid.org/0000-0003-2948-7230)
- Katelyn Cunningham
- Graham Blackwood
- Ryan Goodson
- Heather M Wilkins
Institutions
- University of Kansas (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103467
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00