Influence of ancestry in mitochondrial processes in APOE4 carriers of Alzheimer's Disease
Our ancestry-specific analysis of snRNA-seq in AD provides a unique overview into the underlying changes in mitochondrial processes in APOEe4 AD carriers. This study suggests that ancestry differences in mitochondrial processes might underly the AD risk difference observed for EU and AF populations. Whether these transcriptional differences in mitochondrial gene expression are associated with the higher levels in APOE expression seen in EU individuals is still unknown but subject of future research.
Authors
- Daniel A. Dorfsman
- Patrice Whitehead
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Juan I. Young
- C. Alba
- Theresa Schuck
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Changiz Geula (ORCID: https://orcid.org/0000-0002-9311-3295)
- E. H. Bigio
- Katrina Celis
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Jeffery M. M Vance
- Maria Malane Magalhães Muniz (ORCID: https://orcid.org/0000-0003-0975-7926)
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Marsel Mesulam
- Sandra Weintraub
- Margaret Pericak‐Vance
- Jonathan L Haines
- Farid Rajabli
- David A. Davis
- David A. A. Bennett
Institutions
- Northwestern University (US)
- Henry M. Jackson Foundation (US)
- University of Miami (US)
- Uniformed Services University of the Health Sciences (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Dr. John T. Macdonald Foundation (US)
- Institute on Aging (US)
- Rush University (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104961
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00