P2RX7 deficiency prevents tau‐mediated neurodegeneration via regulation of microglial response and suppression of extracellular vesicles containing tau and toxic mitochondrial content
Our study demonstrated a microglial P2RX7-EV axis with potential implications on neuroinflammation and neurodegeneration associated with tau pathology, further indicating the therapeutic potential of targeting P2rx7 to ameliorate AD progression.
Authors
- Tsuneya Ikezu (ORCID: https://orcid.org/0000-0002-3979-8596)
- Y. Nancy You (ORCID: https://orcid.org/0000-0002-3637-1116)
- Seiko Ikezu (ORCID: https://orcid.org/0000-0001-9879-730X)
- Zhewei Liang
- J. W Ellison
- Stephanie Radhakishun
- Mohammad Abdullah
- Arun Reddy Ravula
- Victor Bodart Santos
Institutions
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103649
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00