Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment

Our findings suggest that disrupted PNNs in the hippocampal CA2 region contribute to social memory dysfunction in the 5XFAD mouse model of AD. Targeting ECM remodeling enzymes to prevent PNN disruption may offer a promising therapeutic strategy for addressing memory deficits associated with AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_103261
Primary Topic
Proteoglycans and glycosaminoglycans research
Type
article
Field-Weighted Citation Impact
0.00
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article

Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment

Lata Chaunsali
Alzheimer s & Dementia
Proteoglycans and glycosaminoglycans research
article

Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment

Lata Chaunsali
article en

Abstract

Our findings suggest that disrupted PNNs in the hippocampal CA2 region contribute to social memory dysfunction in the 5XFAD mouse model of AD. Targeting ECM remodeling enzymes to prevent PNN disruption may offer a promising therapeutic strategy for addressing memory deficits associated with AD.

Alzheimer s & DementiaVol. 21(S1)
University of Virginia (US)
Reduced inequalities
Openalex Percentile: Top 34%
Proteoglycans and glycosaminoglycans research
DOIOpen Access PDFOpenAlex
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Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment — Lata Chaunsali · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS