The Ketogenic Diet Restores Brain Metabolism and Gut Microbiome Composition in Female APOE4 Transgenic Mice: A Multiomics Approach
The KD effectively restored brain metabolism and gut microbiome diversity in APOE4 female mice. These effects were absent in APOE3 mice and APOE4 males. Correlations between microbes and metabolites provide potential targets for AD interventions and risk assessment.
Authors
- Ai‐Ling Lin
- Meera Govindarajan
- Skyler T. Kramer
- Aaron C. Ericsson (ORCID: https://orcid.org/0000-0002-3053-7269)
- Chetan Aware
- Lucille M. Yanckello
- Andrew Yackzan
- Kira L. Ivanich
- Ya‐Hsuan Chang (ORCID: https://orcid.org/0000-0002-0743-4819)
Institutions
- University of Kentucky (US)
- University of Missouri (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104646
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00