Characterization of a <i>Mapt</i> knock‐out rat: Sex‐dependent effects on LTP and object location memory
Our findings provide evidence of a beneficial impact of long-term tau deletion on synaptic plasticity and OLM, underscoring the potential for tailoring tau-lowering therapeutics by age, sex and brain region once the underlying mechanism is fully elucidated.
Authors
- Liam T. Ralph (ORCID: https://orcid.org/0000-0002-5199-2666)
- Ashish Kadia
- John Georgiou (ORCID: https://orcid.org/0000-0003-4503-6384)
- Patrick Tidball (ORCID: https://orcid.org/0000-0002-8983-1905)
- John Howland
- Meng Tian
- Aiden E Glass
- Graham L Collingridge
- Kaylen M Young
- Dan McElroy
Institutions
- University of Toronto (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- University of Saskatchewan (CA)
- Occupational Cancer Research Centre (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102955
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00