Protein‐Protein Interaction Analysis of Osteopontin (SPP1) in Alzheimer's Disease

SPP1 is crucial in AD, interacting with APP and MAPT, activating the NF-κB pathway, amplifying neuroinflammation, and exacerbating neuronal damage. Elevated SPP1 expression correlates with increased APP, MAPT, and inflammatory cytokines. Periodontal infections that raise osteopontin levels may accelerate AD progression, suggesting modulation of osteopontin and control of periodontal inflammation as promising therapeutic strategies.