Genetic associations of plasma biomarkers of neurodegeneration in a population of laboratory marmosets
Variation in AD-relevant biomarkers in marmosets were not explained solely by age, suggesting a strong potential genetic contribution. Our work aims to leverage possible heritable associations with disease markers discovered in the marmosets to explain the progression of neurodegeneration, which could directly provide insights into human AD biology from a genetic point of view.
Authors
- Yongshan Mou
- Seung‐Kwon Ha
- Takeshi Murai (ORCID: https://orcid.org/0000-0002-0429-4195)
- Sangho Choi (ORCID: https://orcid.org/0009-0006-9106-7818)
- Catrina Spruce
- Hasi Huhe
- Annat Haber (ORCID: https://orcid.org/0000-0001-8407-9171)
- Gregg E. Homanics (ORCID: https://orcid.org/0000-0003-3641-8153)
- Brianne Stein
- Laura M. Schultz (ORCID: https://orcid.org/0000-0001-7506-8235)
- Lauren S. Bailey (ORCID: https://orcid.org/0000-0002-7155-5877)
- Stephanie Hachem
- Lauren Mongeau
- Andrew DeSana (ORCID: https://orcid.org/0009-0009-4361-7637)
- Sonal Kumar (ORCID: https://orcid.org/0000-0002-6873-6933)
- Lauren K Hayrynen Schaeffer
- Afonso C Silva
- Jung Eun Park
- Stacey J Sukoff Rizzo
- Gregory W Carter
Institutions
- Tufts University (US)
- University of Pittsburgh (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103724
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00