Selective targeting of trans‐synaptic tau using chimeric antibodies receptors tethered to the synaptic membrane
Overall, these data suggest a novel mechanism for targeting proteins either in the synaptic cleft or within the post-synaptic membrane and provides an effective approach for isolating and identifying propagating tau species. AbbVie Disclosure Statement: All authors are employees of AbbVie. The design, study conduct, and financial support for this research were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the publication. No honoraria or payments were made for authorship.
Authors
- Dhaval Nanavati
- Sharmin Afroz (ORCID: https://orcid.org/0000-0002-8778-3313)
- Justine D. Manos (ORCID: https://orcid.org/0000-0002-4265-4016)
- Wendy Ritacco
- Lionel Galibert (ORCID: https://orcid.org/0000-0002-2619-2464)
- Christina N Preiss
- Jessica Wu (ORCID: https://orcid.org/0000-0002-0181-9398)
- Jonathan A. Sreter (ORCID: https://orcid.org/0000-0001-9562-741X)
- Xavier Langlois (ORCID: https://orcid.org/0000-0001-7690-9710)
- H. Wu
- Kiran Yanamandra (ORCID: https://orcid.org/0000-0002-4908-5848)
- Iwan Parfentev (ORCID: https://orcid.org/0000-0002-0203-2167)
- Nandini Romanul
- Robert Kupp
- Alessandra M Welker
- Rebecca Sebastian
Institutions
- Ludwigshafen University of Business and Society (DE)
- AbbVie (United States) (US)
- Klinikum Ludwigshafen (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103576
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00