Visceral Adipose Tissue from Obese and Diabetic Mice Induces Tau Pathogenesis
Overall, our study highlights a novel interplay between AD and metabolic disorders, demonstrating that visceral adipose tissue from both genetically obese/diabetic and diet-induced obese mice exacerbates tau pathology via immune system activation. These findings reinforce the role of metabolic dysfunction in AD and suggest visceral adipose tissue as a potential target for therapeutic intervention.
Authors
- Juana Andreo‐Lopez (ORCID: https://orcid.org/0000-0003-2180-0560)
- David Baglietto‐Vargas (ORCID: https://orcid.org/0000-0003-1441-3175)
- Miriam Bettinetti‐Luque (ORCID: https://orcid.org/0009-0002-5177-9264)
- Laura Trujillo‐Estrada (ORCID: https://orcid.org/0000-0001-6696-4505)
- Antonia Gutiérrez
- Elisabeth Sánchez‐Mejías
- Cynthia Campos‐Moreno
- Frank M LaFerla
- Mario Morales‐Cabello
- Ian Perea‐Santaella
- Celia Da Cunha
- Raquel Sanchez‐Varo
Institutions
- University of California, Irvine (US)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105597
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00