Evidence of Early <i>APOE4‐</i> Related Vulnerabilities in Memory Systems in Midlife Women
Female midlife APOE4 carriers have decreased activity and connectivity in key memory regions during word encoding compared to non-carriers, despite showing similar cognitive performance and plasma amyloid and tau levels. Associations of certain connectivity outcomes with AD biomarkers suggest relevance to AD pathogenesis. These functional brain patterns may emerge earlier than the adverse effects of APOE4 genotype on cognition and brain.
Authors
- Katrina A. Wugalter (ORCID: https://orcid.org/0000-0002-6555-4448)
- Carol A. Derby (ORCID: https://orcid.org/0000-0002-5657-4519)
- Rebecca C. Thurston (ORCID: https://orcid.org/0000-0001-6580-1202)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Pauline M. Maki (ORCID: https://orcid.org/0000-0002-8443-3430)
- Minjie Wu (ORCID: https://orcid.org/0000-0002-8978-3851)
- M. Ilyas Kamboh
Institutions
- Albert Einstein College of Medicine (US)
- University of Pittsburgh (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099115
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00