Preliminary and Ongoing Investigation of Human Induced Pluripotent Stem Cell‐Derived Frontotemporal Dementia Cortical Organoids Assessed by Mass Spectrometry
This study leverages human induced pluripotent stem cell-derived MAPT<sup>V337M</sup> cortical organoids as a model to explore frontotemporal dementia-associated proteomic changes. The observation that time impacts protein composition more than genotype suggests the importance of temporal dynamics in organoid development. This study serves as a template for examining other genetic mutations linked to dementia.
Authors
- Jonathan Z. Sexton (ORCID: https://orcid.org/0000-0002-9244-5888)
- Merci N Best (ORCID: https://orcid.org/0000-0002-2602-8437)
- Jared Lamp (ORCID: https://orcid.org/0000-0002-7187-7657)
- İlkim Ertürk
- Andrew Umstead
- Henry L. Paulson (ORCID: https://orcid.org/0000-0002-0382-7535)
- EM Tank
- Sami J. Barmada (ORCID: https://orcid.org/0000-0002-9604-968X)
- A. John Spencer
- Irving Vega
- Mariana Sierra
Institutions
- University of Michigan (US)
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102339
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00