Phosphorothiolation of Benzylic C(sp <sup>3</sup> )–H via EnT-Mediated Radical–Radical Cross-Coupling
Direct phosphorothiolation of benzylic C(sp<sup>3</sup>)-H bonds remains underexplored. Herein, we report an energy transfer (EnT)-mediated method that achieves this via controlled radical-radical cross-coupling, using inexpensive K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> as both an oxidant and a hydrogen atom transfer (HAT) reagent. This strategy eliminates prefunctionalization steps, demonstrates excellent chemoselectivity, and provides an atom- and step-economical route to diverse alkyl phosphorothioate compounds.
Authors
- Longyu Wang (ORCID: https://orcid.org/0000-0002-8752-7299)
- Xinyi Guo (ORCID: https://orcid.org/0000-0001-5416-7787)
- Yan Gao
- Mengke Yang
- Pengbo Zhang
Institutions
- Chinese Academy of Sciences (CN)
- Fujian Institute of Research on the Structure of Matter (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c04989
- Citations
- 1
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94