Multispectral organelle imaging to model differentiation and neurodegeneration

We uncovered a novel role for VAPB-mediated ER-peroxisome contacts in neuronal differentiation, suggesting that multi-spectral imaging can be used to interrogate organelle morphology and contacts during neuronal differentiation and neurodegeneration. As a future direction, we will use this method to reveal defects in organelle communication networks in iNeurons with AD-associated mutations.