Longitudinal Changes in Alzheimer's Disease Imaging Biomarkers in a Genetically Modified Rat Model of Amyloidosis

These findings suggest that during the early stages of Aβ deposition, there is a simultaneous increase in glucose metabolism and glial reactivity. This is followed by a transient decrease in glial reactivity, with a resurgence of glial activation in later stages, while glucose metabolism remains elevated. This supports the hypothesis that amyloid deposition triggers both early and late neuroinflammatory responses. The persistent hypermetabolism observed reinforces that murine models are more resilient to amyloid pathology. These results underscore the value of an imaging platform to study the temporal progression of amyloid pathology in genetically modified rodent models with strong translational relevance.