Deficiency of the Alzheimer's disease gene SORL1 impairs lysosomal enzyme trafficking in human microglia
Our findings further substantiate the microglial endo-lysosomal network as a potential novel pathway through which SORL1 may increase AD risk and contribute to development of AD. Additionally, our findings may inform development of novel lysosome and microglia associated drug targets for AD.
Authors
- Beth Stevens (ORCID: https://orcid.org/0000-0003-4226-1201)
- Sonia B. Sidhu (ORCID: https://orcid.org/0000-0003-4117-638X)
- Nader Morshed (ORCID: https://orcid.org/0000-0002-0346-9651)
- Suman Jayadev (ORCID: https://orcid.org/0000-0003-3164-9665)
- Jessica E. Young
- Swati Mishra
Institutions
- Broad Institute (US)
- University of Washington (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_099991
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00