Environment‐susceptible genetic loci for imaging‐based preclinical markers of ADRD, and the influence of modifiable risk factors

Our study identifies novel genome-wide loci that interact with environmental factors and are associated with preclinical MRI markers of AD. These findings underscore the impact of modifiable lifestyle factors on genetic risk, offering potential avenues for preventive and therapeutic strategies. Ongoing efforts aim to replicate these findings in well-characterized cohorts, including the Framingham Heart Study and the San Antonio Family Heart Study of predominantly Mexican-Americans.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_103860
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Environment‐susceptible genetic loci for imaging‐based preclinical markers of ADRD, and the influence of modifiable risk factors

Xueqiu Jian, Francesco Paolo Casale, J. Blangero, Chakkarai Sathyaseelan et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Environment‐susceptible genetic loci for imaging‐based preclinical markers of ADRD, and the influence of modifiable risk factors

Xueqiu Jian, Francesco Paolo Casale, J. Blangero, Chakkarai Sathyaseelan, Mohsen Sharifi Tabar, Claudia L Satizabal, Juan B Gutiérrez, Sudha Seshadri, Mohamad Habes, Muralidharan Sargurupremraj
article en

Abstract

Our study identifies novel genome-wide loci that interact with environmental factors and are associated with preclinical MRI markers of AD. These findings underscore the impact of modifiable lifestyle factors on genetic risk, offering potential avenues for preventive and therapeutic strategies. Ongoing efforts aim to replicate these findings in well-characterized cohorts, including the Framingham Heart Study and the San Antonio Family Heart Study of predominantly Mexican-Americans.

Alzheimer s & DementiaVol. 21(S1)
Boston University (US), The University of Texas at San Antonio Health Science Center (US), The University of Texas Rio Grande Valley (US), Helmholtz Zentrum München (DE), The University of Texas at San Antonio (US), Technical University of Munich (DE)
Openalex Percentile: Top 34%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Environment‐susceptible genetic loci for imaging‐based preclinical markers of ADRD, and the influence of modifiable risk factors — Xueqiu Jian, Francesco Paolo Casale, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS