Investigating the Shared Genetic Architecture Between Kidney Function and Alzheimer's Disease Across Ancestries

Our findings reveal components of shared genetic architecture between AD and kidney function, characterized by a mixture of concordant and discordant associations that are likely driven by specific biological pathways rather than genome-wide effects. We will focus on refining these associations to determine directionality and causality, identifying key genes driving strong local genetic correlations and their biological pathways, and integrating chronic kidney disease associations alongside eGFR to capture phenotypic variability.