Molecular insights into shared and distinct etiologies of Alzheimer's disease and major depressive disorder at single‐nucleus resolution

Our single-cell analysis provides mechanistic insights into the shared and divergent molecular etiologies, dysregulated pathways, and impaired cellular communications between LOAD and MDD. This knowledge has a translational impact toward the identification of actionable targets as novel therapies to treat depression symptoms earlier in disease stages as a mean to delay or alleviate depression onset in LOAD.