Photobiomodulation mitigates chondrocyte catabolism in osteoarthritis by modulating macrophage M1 polarization through the IL-6/JAK/STAT pathway
Our study demonstrated that PBM intervention mitigated OA progression by regulating macrophage polarization through the IL-6/JAK/STAT pathway, emphasizing the therapeutic potential of immune modulation in OA management. These findings provide a mechanistic basis for PBM intervention as a nonpharmacological strategy for joint degeneration.
Authors
- Wenhua Ning
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Jing Nie
- S. Du
- H Wang (ORCID: https://orcid.org/0000-0002-5613-170X)
- Yiying Liu
Institutions
- Henan University of Technology (CN)
- Henan Communication Science and Technology Research Institute (China) (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou University of Industrial Technology (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s13018-025-06506-4
- Primary Topic
- Laser Applications in Dentistry and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Education Department of Henan Province
- First Affiliated Hospital of Zhengzhou University