TDP‐43 dysfunction and markers in Neurodegenerative Disease

TDP-43 co-pathology has a profound effect on AD pathogenesis that may be intrinsically linked to a disruption of the endolysosomal pathway in neurons. Exploring the consequences of TDP-43 dysfunction in the brain can open new avenues for AD biomarker and therapeutic development.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_104405
Primary Topic
Lysosomal Storage Disorders Research
Type
article
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article

TDP‐43 dysfunction and markers in Neurodegenerative Disease

Leonard Petrucelli
Alzheimer s & Dementia
Lysosomal Storage Disorders Research
article

TDP‐43 dysfunction and markers in Neurodegenerative Disease

Leonard Petrucelli
article en

Abstract

TDP-43 co-pathology has a profound effect on AD pathogenesis that may be intrinsically linked to a disruption of the endolysosomal pathway in neurons. Exploring the consequences of TDP-43 dysfunction in the brain can open new avenues for AD biomarker and therapeutic development.

Alzheimer s & DementiaVol. 21(S1)
WinnMed (US), Mayo Clinic in Florida (US)
Openalex Percentile: Top 34%
Lysosomal Storage Disorders Research
DOIOpen Access PDFOpenAlex
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TDP‐43 dysfunction and markers in Neurodegenerative Disease — Leonard Petrucelli · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS