The HET3 mouse as a model of age‐dependent dendritic spine loss, proteome alterations, and cognitive decline
The HET3 mouse may be a viable model for studies designed to test candidate interventions for their abilities to slow age-dependent spine loss and protect against cognitive decline. Additional studies with larger sample sizes of both sexes designed to replicate age-dependent spine loss in HET3 are warranted.
Authors
- Josh M. Krivinko (ORCID: https://orcid.org/0000-0003-3748-6510)
- Robert A. Sweet (ORCID: https://orcid.org/0000-0001-9154-9709)
- Jason T. Newman
- Susan Erickson
- Matthew L MacDonald
- Stacey J Sukoff Rizzo
- Akayla Lewin
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103190
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00