Differential Roles of Human 3R and 4R Tau in the Modulation of Inflammation and Development of Neuropathology
This new mouse model of tauopathy more completely recapitulates the pattern, severity and accumulation of tau and associated neuropathology and behavioral changes observed in human tauopathies such as AD. 3R/4Rtau-tg bigenic miceshould supplant existing single transgenic tau models for general validation of therapeutic targets and investigations of novel therapies on tauopathy endpoints.
Authors
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Brian Spencer (ORCID: https://orcid.org/0000-0002-7486-1941)
- Aaron Schueler
- Daniel Sung
Institutions
- University of Southern California (US)
- Autism Research Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105749
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00