A cholesterol‐coupled <i>N</i> ‐acetyl‐aspartyl‐glutamate metabolic network facilitates the neuroprotective impact of progesterone‐estradiol crosstalk in neurons

Collectively, our work reveals an unforeseen interaction cholesterol balance and mitochondrial energy production in neurons. The findings also shed light on the potential impact of estrogen dominance during the perimenopausal transition, contributing to increased susceptibility to AD/ADRD among aging women.