Analysis of 36,361 whole genome sequenced samples from the Alzheimer's Disease Sequencing Project (ADSP)
Analyses of ADSP WGS data identified a novel genome-wide significant association at LMO1 (11p15), a gene involved in transcriptional regulation with potential relevance to neuronal health, and a suggestive association at TNS1 (2q35), previously linked to cognitive decline in non-demented older adults. Further studies in diverse populations from the ADSP are expected to uncover additional common and rare variant associations, offering new insights into ADRD pathogenesis.
Authors
- Congcong Zhu (ORCID: https://orcid.org/0000-0002-0143-7453)
- Bilçağ Akgün (ORCID: https://orcid.org/0000-0002-5220-5652)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Seung Hoan Choi (ORCID: https://orcid.org/0000-0002-2797-3190)
- Nicholas A. Kushch
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Kyle Scott
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- John J. Farrell (ORCID: https://orcid.org/0000-0001-6502-1572)
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Dongyu Wang (ORCID: https://orcid.org/0000-0002-1317-2739)
- Jiemin Yang
- Anita L. DeStefano
- Jonathan L Haines
- Gina M. Peloso
- Brian W Kunkle
- The Alzheimer's Disease Neuroimaging Initiative (ADNI)*; Alzheimer's Disease Genetics Consortium (ADGC); The Alzheimer's Disease Sequencing Project (ADSP)
- Susan H. Slifer
Institutions
- Boston University (US)
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106038
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00