Association between soluble TREM2, APOE genotype, Alzheimer's copathology and disease evolution in dementia with Lewy bodies
APOEε4 carriage attenuates the TREM2-dependent microglial response in prodromal DLB, as reflected by lower CSF cTREM2 levels. Elevated cTREM2 levels in the prodromal phase are associated with slower cognitive decline, suggesting a protective role of microglial activation during early disease stages. These findings suggest an early modulation of TREM2-driven microglial response by APOEε4 which influences DLB progression.
Authors
- Estrella Morenas‐Rodríguez (ORCID: https://orcid.org/0000-0002-7591-6051)
- Adolfo Gómez‐Grande (ORCID: https://orcid.org/0000-0002-7925-8826)
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Christian Haass
- Daniel Alcolea
- Alberto Lleó
- Isabel Sala
- Valle Camacho
- Lídia Vaqué‐Alcázar
- Elena Vera
- Álex Fernández‐León
- Íñigo Rodríguez‐Baz
- Pablo Zaragoza‐Ballester
- Briggitte Nuscher
Institutions
- Universidad Complutense de Madrid (ES)
- Universitat Autònoma de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- German Center for Neurodegenerative Diseases (DE)
- Hospital de Sant Pau (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Hospital Universitario 12 De Octubre (ES)
- Munich Cluster for Systems Neurology (DE)
- Fundació Catalana per a la Recerca i la Innovació (ES)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102529
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00