Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced <scp>ANCA</scp> Vasculitis: A Case Report

Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking Cryptococcus infection. Despite these histological findings, the cryptococcoid variant of Sweet syndrome is not an infectious process. This delineation is essential for the initiation of proper treatment. Here, we present a patient with cryptococcoid Sweet syndrome with concomitant hydralazine-induced ANCA vasculitis, which has seldom been reported in the literature.

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Publication Details

Journal
Journal of Cutaneous Pathology
Published
2025-12-24
DOI
https://doi.org/10.1111/cup.70044
Primary Topic
Autoimmune and Inflammatory Disorders
Type
article
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article

Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced ANCA Vasculitis: A Case Report

Kathryn Lynam, Laura Winterfield, Amanda Ederle, Jenna Vroman et al.
Journal of Cutaneous Pathology
Autoimmune and Inflammatory Disorders
article

Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced ANCA Vasculitis: A Case Report

Kathryn Lynam, Laura Winterfield, Amanda Ederle, Jenna Vroman, Pelin Sagut
article en

Abstract

Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking Cryptococcus infection. Despite these histological findings, the cryptococcoid variant of Sweet syndrome is not an infectious process. This delineation is essential for the initiation of proper treatment. Here, we present a patient with cryptococcoid Sweet syndrome with concomitant hydralazine-induced ANCA vasculitis, which has seldom been reported in the literature.

Journal of Cutaneous PathologyVol. 53(4)
Medical University of South Carolina (US)
Good health and well-being
Openalex Percentile: Top 30%
Autoimmune and Inflammatory Disorders
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