Reduced expression of mitochondrial lactamases in myeloid cells might be protective for AD
LACTB may play a role in cell differentiation and response to stimuli in myeloid cells by modifying mitochondrial respiration and lipid metabolism. Unlike other AD risk genes, LACTB encodes an enzyme, reduced expression is protective, and succinyl-carnitine can be used as a biomarker, which highlights it as a promising AD therapeutic target.
Authors
- Wen Yi See
- Jiacheng Ma (ORCID: https://orcid.org/0000-0002-4767-6150)
- Hayk Davtyan (ORCID: https://orcid.org/0000-0001-8554-6456)
- Edoardo Marcora (ORCID: https://orcid.org/0000-0002-3829-4927)
- Tulsi Patel (ORCID: https://orcid.org/0000-0002-2797-1443)
- Carmen Romero Molina
- Ruben Gomez‐Gutierrez (ORCID: https://orcid.org/0000-0001-9134-4375)
- Alison Goate (ORCID: https://orcid.org/0000-0002-0576-2472)
- Mathew Blurton‐Jones
- Jim Ray
Institutions
- Alzheimer's Drug Discovery Foundation (US)
- University of California, Irvine (US)
- The University of Texas Health Science Center at Houston (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_099086
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00