Investigation of Alzheimer's Disease‐Associated effect of SPOCK1 Protein on Apoptosis in Nerve Cells

For the first time we have shown localization of SPOCK1 in mitochondria in astroglia, microglial, and neuroblastoma cell lines, and studied SPOCK1's effect on cell death in these cell lines. The SPOCK1 overexpression in astrocytes increased apoptosis, highlighting its potential role in cell death. Overall our findings suggest a potantial role for SPOCK1 in Alzheimer's etiology and introducing it as a novel molecule in neurodegenerative diseases.