Divergent trajectories of brain ageing across the seventh decade predict AD pathology in a UK population‐based birth cohort
An identically-aged population experienced heterogenous trajectories of proteomic brain ageing across their seventh decade. Accelerating brain ageing was predictive of AD biomarker positivity, independent of non-specific measures of neurodegeneration and genetic risk. Future research will explore how implicated proteins may couple brain ageing to AD pathology.
Authors
- Andrew L. Wong (ORCID: https://orcid.org/0000-0002-0595-6939)
- Amelia Farinas (ORCID: https://orcid.org/0000-0002-6697-8883)
- Ashvini Keshavan (ORCID: https://orcid.org/0000-0003-1043-5721)
- Hamilton Se‐Hwee Oh (ORCID: https://orcid.org/0000-0001-8192-7593)
- William Coath (ORCID: https://orcid.org/0000-0002-3976-9461)
- Alina A. Isakova (ORCID: https://orcid.org/0000-0003-1113-6889)
- J. R. Groves
- Patricia Moran‐Losada
- Veronica Augustina Bot (ORCID: https://orcid.org/0009-0008-5060-1142)
- Tony Wyss‐Coray
- Jennifer M Nicholas
- Jonathan M Schott
- Sarah‐Naomi James
- Dylan M Williams
- Marcus Richards
Institutions
- Neurosciences Institute (US)
- London School of Hygiene & Tropical Medicine (GB)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Medical Research Council (GB)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100995
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00