Identification and validation of ferroptosis-related key hub genes linking hypoxia and osteoporosis
In summary, we first screened ferroptosis-related key hub genes linking hypoxia and osteoporosis. The findings suggest that JUN, SQSTM1, STAT3 , CD44 and TGFBR1 are significantly associated with OP and hypoxia, potentially serving as biomarkers for diseases linked to ferroptosis. Additionally, hsa-miR-20a-5p was identified as a crucial upstream regulator likely involved in the regulation of these genes simultaneously.
Authors
- Yuhu Chen
- Y. Wang (ORCID: https://orcid.org/0000-0002-0271-626X)
- L. Wang
- Yu Gu (ORCID: https://orcid.org/0000-0003-4181-6041)
- Qingsong Gu
- Yiheng Li
- Min Yang
- Ziru Wang
- Jianqiao Li
Institutions
- Shandong University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12891-025-09326-z
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wannan Medical College